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Annual Review of Immunology

Volume 41, 2023

Complement in the Brain: Contributions to Neuroprotection, Neuronal Plasticity, and Neuroinflammation

Abstract

The complement system is an ancient collection of proteolytic cascades with well-described roles in regulation of innate and adaptive immunity. With the convergence of a revolution in complement-directed clinical therapeutics, the discovery of specific complement-associated targetable pathways in the central nervous system, and the development of integrated multi-omic technologies that have all emerged over the last 15 years, precision therapeutic targeting in Alzheimer disease and other neurodegenerative diseases and processes appears to be within reach. As a sensor of tissue distress, the complement system protects the brain from microbial challenge as well as the accumulation of dead and/or damaged molecules and cells. Additional more recently discovered diverse functions of complement make it of paramount importance to design complement-directed neurotherapeutics such that the beneficial roles in neurodevelopment, adult neural plasticity, and neuroprotective functions of the complement system are retained.

Keyword(s): Alzheimer disease, C1q, complement, microglia, neuroinflammation, synaptic pruning
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/content/journals/10.1146/annurev-immunol-101921-035639
2023-04-26
2024-04-28
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/content/journals/10.1146/annurev-immunol-101921-035639
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Complement in the Brain: Contributions to Neuroprotection, Neuronal Plasticity, and Neuroinflammation
Annual Review of Immunology 41, 431 (2023); https://doi.org/10.1146/annurev-immunol-101921-035639
/content/journals/10.1146/annurev-immunol-101921-035639
/content/journals/10.1146/annurev-immunol-101921-035639
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